ii.
Colonoscopy Preparation (Miralax)
This guide will help you prepare for your colonoscopy at Sulphur Surgical Clinic
using polyethylene glycol (MiraLAX), bisacodyl
(Dulcolax), and simethicone. A clean colon is essential —
if stool remains, your surgeon may not be able to see polyps or other problems
clearly, and the procedure may need to be repeated.
Read these instructions all the way through when you receive them, then keep
this page open the day before your procedure to follow the timeline. Your exact
dosing schedule depends on whether your colonoscopy is in the morning
(Standard Prep) or the afternoon (Split-Dose Prep) — both are laid
out below. Questions at any point — call (337) 527-6363.
↓ Download / print prep instructions Colonoscopy Prep Instructions – Miralax · PDF
Quick reference — prep day timeline
Which prep should you follow? It depends on your procedure time.
Use the Standard Prep if your colonoscopy is in the
morning (arrival before noon), or the Split-Dose Prep
if it's in the afternoon (arrival at noon or later). Split-dose gives
the clearest view and is preferred when your procedure time allows it. Not sure of your
arrival time? Call (337) 527-6363.
Standard Prep — morning colonoscopy
| Time | What to do |
| Morning of day before | Mix all 238 g Miralax with 64 oz clear liquid; refrigerate |
| All day before | Clear liquid diet — at least 8 oz every hour; nothing red, purple, or orange |
| 3:00 PM | 2 Dulcolax + 2 simethicone (160 mg), with water |
| 3:15 – 4:00 PM | First half of Miralax — one 8 oz glass every 15 min (4 glasses) |
| 7:00 PM | 2 Dulcolax + 2 simethicone (160 mg), with water |
| 7:15 – 8:00 PM | Second half of Miralax — one 8 oz glass every 15 min (4 glasses) |
| 4 hr before arrival | Stop all liquids — nothing by mouth until after your procedure |
Split-Dose Prep — afternoon colonoscopy
| Time | What to do |
| Morning of day before | Mix all 238 g Miralax with 64 oz clear liquid; refrigerate |
| Day before, all day | Clear liquid diet — at least 8 oz every hour; nothing red, purple, or orange |
| Day before · 5:00 PM | 2 Dulcolax + 2 simethicone (160 mg), with water |
| Day before · 5:15 – 6:00 PM | First half of Miralax — one 8 oz glass every 15 min (4 glasses) |
| Day of · 6 hr before arrival | 2 Dulcolax + 2 simethicone (160 mg), with a small glass of water |
| Day of · 5 hr 45 min – 5 hr before | Second half of Miralax — one 8 oz glass every 15 min (4 glasses) |
| Day of · 5 hr before arrival | Stop all liquids — nothing by mouth until after your procedure |
1 week before your procedure
Arrange a ride home. You must have a responsible care partner
drive you home — someone who can get you there safely and report any concerns
to your team. Plan this before procedure day.
Talk to your doctor about your medications. Some need to be
stopped before your procedure. Common examples:
- Fish oil — stop 1 week before
- Metformin (including Glucophage, Janumet, or any product containing metformin) — do not take the day before or the day of
- Ozempic, Wegovy, Mounjaro, or any semaglutide / tirzepatide — hold for 1 full week before your procedure
- Iron supplements — stop 5 days before (covered below)
- Insulin or other diabetes medications — your prescribing doctor will adjust your dose; tell them you'll be on a sugar-free clear-liquid diet the day before
If you take a blood thinner — see the full list and instructions
Ask the doctor who prescribes your blood thinner when to stop it before
your procedure. Do not stop a blood thinner without asking the
prescribing physician. Common blood thinners include:
- Eliquis (apixaban)
- Pletal (cilostazol)
- Plavix (clopidogrel)
- Fragmin (dalteparin)
- Lovenox (enoxaparin)
- Arixtra (fondaparinux)
- Heparin
- Xarelto (rivaroxaban)
- Innohep (tinzaparin)
- Coumadin (warfarin)
- Aspirin
Buy your supplies
- 4 (5 mg) tablets of Dulcolax (bisacodyl) — usually sold as a box of 10
- 1 (238 gram) bottle of Miralax (polyethylene glycol)
- Simethicone — 80 mg tablets, soft-gels, or chewables (at least 4 tablets / 320 mg total). Brand names include Gas-X, Mylicon, and Phazyme. Generic store-brand is equally effective.
- 64 ounces of clear liquid that is not red, purple, or orange to
mix with the Miralax. Keep at room temperature. A sports drink like
Gatorade or Powerade is a good choice — it replaces electrolytes you'll
lose during the prep. If you have diabetes, use a sugar-free
sports drink.
Why simethicone? It breaks up the gas bubbles and foam that
collect in your colon during the prep. Removing those bubbles gives your surgeon
a clearer view of the colon lining and helps catch small polyps that bubbles can
hide. It's safe, inexpensive, and available over the counter.
5 days before your procedure
Stop iron supplements. Iron causes color changes in stool that
make the colon lining harder to see.
3 days before your procedure
Start a low-fiber diet. During this period, do not eat:
- Raw (fresh) fruits and vegetables
- Whole kernel corn, including canned
- Whole grains (oatmeal, brown rice, quinoa, wheat bread)
- Seeds (sesame, poppy) or nuts
2 days before your procedure
Most patients — if you're not usually constipated, don't take
opioid medications, and haven't had a prior colonoscopy with poor prep — just
continue the low-fiber diet (no raw fruits/vegetables, whole kernel corn,
grains, seeds, or nuts). Skip to "The day before" below.
If you are usually constipated, take narcotic medications, or have had
a colonoscopy with a poor prep in the past:
- Take 1 capful (17 g) of Miralax mixed with 8 oz of liquid at breakfast, lunch, and dinner
- Follow a full liquid diet: yogurt (no fruit pieces), fruit juices without pulp, soda, strained broth or cream soups, nutritional supplements like Ensure or Boost, ice cream and fruit ices (no fruit pieces)
The day before your procedure
Morning: Mix all 238 g of Miralax with
64 oz of room-temperature clear liquid until the powder
dissolves. Once dissolved, you can refrigerate it — most people find it tastes
better cold. Do not mix earlier than this morning.
Follow a clear liquid diet all day. Drink at least one 8 oz
glass of liquid every hour while you're awake. If you have diabetes, drink only
sugar-free clear liquids and check your blood sugar often.
OK to drink
- Clear broth, bouillon, consommé
- Gelatin (Jell-O)
- Flavored ices (no fruit pieces)
- Clear fruit juices — apple, white cranberry, lemonade, white grape
- Soda — 7-Up, Sprite, ginger ale
- Gatorade or Powerade
- Black coffee
- Tea
- Water
Do NOT drink
- Anything red, purple, or orange
- Juices with pulp
- Milk or cream
- Alcoholic beverages
- Nectars
- Anything with particles of dried food or seasoning
Start your bowel preparation
Follow only ONE of the two schedules below, based on your procedure
time. Standard Prep is for morning colonoscopies (arrival before
noon); Split-Dose Prep is for afternoon colonoscopies (arrival at
noon or later). If you're unsure of your arrival time, call
(337) 527-6363.
Standard Prep — morning colonoscopy
Complete the entire prep the day before your procedure.
3:00 PM — first dose
Dulcolax + simethicone. Take with a glass of water:
- 2 Dulcolax (bisacodyl) 5 mg tablets
- 2 simethicone 80 mg tablets (160 mg total)
3:15 PM — 4:00 PM — first half of Miralax
Drink one 8 oz glass every 15 minutes:
- 3:15 PM — glass 1
- 3:30 PM — glass 2
- 3:45 PM — glass 3
- 4:00 PM — glass 4
Save the remaining half in the refrigerator for the evening round. Bowel movements
usually begin within 1 hour, but it can take longer for some people — don't worry
if nothing happens right away. Keep drinking clear liquids and start the evening
dose on time. Apply petroleum jelly (Vaseline) or A&D ointment around the anus
after each bowel movement to prevent irritation.
7:00 PM — second dose
Dulcolax + simethicone. Take with a glass of water:
- 2 Dulcolax (bisacodyl) 5 mg tablets
- 2 simethicone 80 mg tablets (160 mg total)
7:15 PM — 8:00 PM — second half of Miralax
Drink one 8 oz glass every 15 minutes:
- 7:15 PM — glass 1
- 7:30 PM — glass 2
- 7:45 PM — glass 3
- 8:00 PM — glass 4
Finish the entire Miralax mixture. Continue drinking clear liquids
until 4 hours before your scheduled arrival time. Do not eat
anything until after your procedure.
Split-Dose Prep — afternoon colonoscopy
Split-dose prep is completed across two days — the evening before
your procedure and the morning of. This timing gives your surgeon the clearest
possible view of your colon and is the preferred protocol when your procedure time
allows it.
Day before · 5:00 PM — first dose
Dulcolax + simethicone. Take with a glass of water:
- 2 Dulcolax (bisacodyl) 5 mg tablets
- 2 simethicone 80 mg tablets (160 mg total)
Day before · 5:15 PM — 6:00 PM — first half of Miralax
Drink one 8 oz glass every 15 minutes:
- 5:15 PM — glass 1
- 5:30 PM — glass 2
- 5:45 PM — glass 3
- 6:00 PM — glass 4
Save the remaining half in the refrigerator for the morning. Keep drinking clear
liquids. Apply petroleum jelly (Vaseline) or A&D ointment around the anus after
each bowel movement to prevent irritation.
Day of · 6 hours before arrival — second dose
Wake up in time to take, with a small glass of water:
- 2 Dulcolax (bisacodyl) 5 mg tablets
- 2 simethicone 80 mg tablets (160 mg total)
Day of · second half of Miralax — finish 5 hours before arrival
Fifteen minutes after your second Dulcolax + simethicone dose, begin the second
half of the Miralax — one 8 oz glass every 15 minutes — so the final glass is
finished exactly 5 hours before your scheduled arrival time.
After you finish, do not eat or drink anything until after your
procedure.
Split-dose timing examples
| Arrival time | Dulcolax + simethicone | Start Miralax | Finish Miralax |
| 12:00 PM | 6:00 AM | 6:15 AM | 7:00 AM |
| 1:00 PM | 7:00 AM | 7:15 AM | 8:00 AM |
| 2:00 PM | 8:00 AM | 8:15 AM | 9:00 AM |
| 3:00 PM | 9:00 AM | 9:15 AM | 10:00 AM |
If you have any questions about your timing, call (337) 527-6363.
Day of your procedure
- Nothing by mouth once you finish your prep — for Standard Prep, stop 4 hours before arrival; for Split-Dose Prep, stop after you finish the morning Miralax (about 5 hours before arrival)
- Take only the medications your surgeon has approved, with a small sip of water
- Wear comfortable, loose-fitting clothing
- Leave jewelry and valuables at home
- Bring photo ID, insurance card, and a list of your medications
- Make sure your ride home is available
CALL US RIGHT AWAY IF YOU NOTICE
- Severe abdominal pain or cramping that does not improve
- Persistent vomiting that prevents you from finishing the prep
- Signs of dehydration — dizziness, dark urine, very dry mouth, lightheadedness when standing
- Any reaction to a prep medication
- Any other concern about your prep or the procedure
Sulphur Surgical Clinic: (337) 527-6363
Monday–Friday, 8:00 AM – 5:00 PM
Devin Seale, MD, FACS • Stephen Castleberry, MD, FACS • Matthew Ayo, MD, FACS
Board-certified general surgeons serving Southwest Louisiana for over 50 years